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filingDate 2016-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106178129-B
titleOfInvention It is loaded with gelatin-calcium alginate core-shell structure sustained-release micro-spheres and preparation method thereof of BMP
abstract A kind of gelatin being loaded with BMP-calcium alginate core-shell structure sustained-release micro-spheres, it successively includes inner nuclear layer and external coating from inside to outside, inner nuclear layer is mainly made of evenly dispersed the gelatine microsphere of bone morphogenetic protein, and the external coating of inner nuclear layer outer cladding is mainly made of calcium alginate.The preparation of the sustained-release micro-spheres includes two ways: first way is first to prepare blank gelatine microsphere, then it is mixed with gelatin/sodium alginate blank nucleocapsid structure sustained-release micro-spheres with sodium alginate, is eventually adding bone morphogenetic protein and obtains the gelatin-calcium alginate core-shell structure sustained-release micro-spheres for being loaded with BMP;The second way is first to prepare the gelatine microsphere for being loaded with BMP, and the gelatin-calcium alginate core-shell structure sustained-release micro-spheres for being loaded with BMP are then mixed to get with sodium alginate.Product of the invention have many advantages, such as had good sustained release effect, Small side effects, it is at low cost, have no toxic side effect.
priorityDate 2016-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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