http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106172238-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2016-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106172238-B |
| titleOfInvention | The construction method of miR-124 knock out mice animal model and application |
| abstract | The invention discloses a kind of miR-124 knock out mice animal model, the mouse model is the mouse for being knocked miR-124-1, miR-124-2, miR-124-3 gene.The present invention uses Crispr-cas9 gene Knockout, has knocked out the highest microRNA gene miR-124 of expression quantity in mouse brain.Mouse obtained shows the nervous system diseases states such as apparent autonomic activities reduce, learning memory declines, soluble amyloid beta increases.It can be the research of the nervous system disease pathology, the screening of nervous system disease agent provides simple, reliable, economic animal model. |
| priorityDate | 2016-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.