| abstract |
The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives of formula (I) and 5,6,7,8-tetrahydro-4H -Pyrazolo[1,5-a][1,4]diazepine derivatives wherein the variables have the meanings defined in the claims. The compounds according to the invention are useful as ROS1 inhibitors. The present invention further relates to methods for the preparation of such novel compounds, pharmaceutical compositions comprising the compounds as active ingredients and the use of the compounds as medicaments. |