| abstract |
The present invention provides an antitumor drug having excellent therapeutic effect which is excellent in antitumor effect and safety. The present invention provides an antibody-drug conjugate, wherein the anti-tumor compound represented by the following formula and the anti-HER3 antibody have the formula: ‑L 1 ‑L 2 ‑L P ‑NH‑(CH 2 )n 1 ‑L a ‑( CH 2 )n 2 ‑C(=O)‑or ‑L 1 ‑L 2 ‑L P ‑represented structure linker coupling (the anti-HER3 antibody is connected to the end of L 1 , the anti-tumor compound is connected to the nitrogen of the 1-position amino The atom is the carbonyl or the C-terminus of LP) at which the linkage site is attached to the -(CH 2 ) n 2 -C(=O)- moiety. |