http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106146502-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 |
| filingDate | 2015-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106146502-B |
| titleOfInvention | Synthetic method and preparation intermediate of Adelaris |
| abstract | The invention provides a method for synthesizing Idelaris, which comprises the following steps: the nitro group is reduced to obtain amino compound II by hydrogen treatment of compound 3 in the presence of a hydrogenation catalyst and a solvent; compound II and N-Boc protected L -2-aminobutyric acid, condensed in the presence of alkali and carboxylic acid activator or in the presence of alkali and condensing agent to obtain Intermediate I; Intermediate I is in a suitable solvent, catalyzed by hexamethyldisilazide/Lewis acid Under the system, the ring-closing reaction is performed to obtain compound 7; compound 7 is reacted with 6-chloro-9-(2-tetrahydropyranyl) purine in a suitable solvent and in the presence of an acid binding agent to obtain compound III; compound III is obtained by using a suitable solvent The reagent removes the protecting group to obtain Idelaris; the reaction scheme is as follows: In the preparation method of the present invention, the reaction conditions of each step are mild, the post-processing is simple and feasible, the total yield is high, and it is environmentally friendly, and is very suitable for industrial production. |
| priorityDate | 2015-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 158.