http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106146394-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-803 |
| filingDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106146394-B |
| titleOfInvention | Hydroxytyrosol nicotinate and its preparation method and application |
| abstract | The invention discloses 3,4- dihydroxyphenyl ethanol nicotinate and its preparation method and application, belong to field of medicine preparing technology, derivation is carried out to the chemical structure of niacin (Niacin), hydroxytyrosol is introduced in its structure, its structure and niacin have larger difference, but have the effects that reduce blood glucose, reduction blood lipid and anti-oxidant.The present invention also provides the preparation methods of compound HT-N, i.e., niacin are reacted to obtain nicotinoyl chlorine with oxalyl chloride, then react into ester with the hydroxytyrosol of benzyl protection, be then deprotected and obtain, and the preparation method is easy to operate, low for equipment requirements, environmental-friendly.New compound 3 disclosed by the invention, 4- dihydroxyphenyl ethanol nicotinate is used to treat the compound of diabetes and hyperlipidemia, it can reduce blood glucose and blood lipid, and it can reduce malonaldehyde, improve the oxidative stress effect under diabetes and hyperlipidemia state, and improves the hepatic injury under diabetic disease states. |
| priorityDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 177.