http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106146360-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C305-24 |
| filingDate | 2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106146360-B |
| titleOfInvention | Method for preparing tyrosine-O-sulfonate |
| abstract | The invention relates to a method for preparing tyrosine-O-sulfonate, which comprises the following steps: (1) reacting a sulfonation reagent with Fmoc protected tyrosine in the presence of a diluent and alkali to obtain a reaction solution; (2) pouring the reaction liquid obtained in the step (1) into a poor solvent, and then standing; (3) decanting the supernatant from step (2), dissolving the residue with water, and adjusting pH to weak acidity with base; (4) washing the aqueous solution obtained in the step (3) with a good solvent, and then concentrating; (5) adding a good solvent into the concentrate obtained in the step (4), stirring, filtering, adding the filtrate into a poor solvent, stirring, collecting solids, and drying to obtain solids; the method avoids the problems of long time consumption and high equipment requirement in distillation, freeze-drying and the like, greatly improves the purity by adding extraction operation in the post-treatment, avoids the use of column chromatography purification operation which is difficult to amplify, and is suitable for amplifying production, simple to operate and high in product purity. |
| priorityDate | 2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.