http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106146355-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C273-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2015-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106146355-B |
| titleOfInvention | The preparation method of leonurine and aspirin conjugate |
| abstract | The invention belongs to medicinal chemistry art, it is related to the synthetic method of leonurine aspirin conjugate.The present invention is using syringic acid, S methyl isothioureas and aspirin as initiation material; respectively through reactions such as acetylation, BOC protections, amidatioon and deacetylations; obtain corresponding construction fragment; finally shared using diisopropylcarbodiimide, 4 dimethylamino naphthyridines and 4 toluene sulfonic acides and be attached three fragments as condensation catalyst, trifluoroacetic acid takes off BOC and protects to obtain target compound.The inventive method is easy to operate, mild condition, and post processing is simple, can improve intermediate leonurine product yieldï¼›Obtained leonurine aspirin conjugate, total recovery 25.27%, is tested through pharmacological activity, the results showed that it has good anti-oxidant, Anti-G value on a cellular level, myocardial cell protection is acted on definite. |
| priorityDate | 2015-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.