| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_883ef14066c153ff611ef557b6c22f71 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C201-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-52 |
| filingDate |
2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4b380e56587a49d7232858fe690594c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6500df1229b0e6af78da87a98b1f16e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5ca03d4e5ca2cbb1e7f09c55195997d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_970314c6726bfe509f6921d0f96c4c15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f530f4c15f2363e8af030fdc331e8ffe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e7f8b2fd8be6c9f60d156d594fa2a4b |
| publicationDate |
2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106146330-A |
| titleOfInvention |
A new method for preparing Eltrombopag intermediate |
| abstract |
The invention provides a method for preparing a compound of formula (I): the method specifically includes the following steps: (1) reacting a compound of formula (II) with a compound of formula (V) under basic conditions to generate a compound of formula (III); (2) (III) compound reacts with compound (VI) under basic conditions in the presence of palladium carbon to generate a compound of formula (IV); (3) compound of formula (IV) reacts in the presence of palladium carbon in the presence of a hydrogen source The compound of formula (I) is generated by reaction under alkaline conditions. The method is ingeniously designed, and the removal of the protecting group is completed together with dechlorination and nitro reduction in the final hydrogenation process, and the resulting compound of formula (I) has high purity; the most critical thing is that compared with other Suzuki coupling reagents, Palladium carbon is cheaper and available from a wide range of sources; after the reaction, it can be directly recycled after simple filtration and separation, which greatly reduces the cost of materials; at the same time, it reduces the discharge of three wastes, which is very suitable for industrial production. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111087315-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109704982-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109704982-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107021928-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107021928-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112979481-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112979481-A |
| priorityDate |
2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |