http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106137994-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2068 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 |
| filingDate | 2016-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106137994-B |
| titleOfInvention | A kind of stable tablet of clopidogrel and preparation method thereof |
| abstract | The invention provides a stable tablet of clopidogrel and a preparation method thereof. Airgel-gluten powder is used as a stable carrier of clopidogrel, and its elastic viscoelastic properties and microscopic network structure make clopidogrel dry It is protected from the chiral inversion and degradation of clopidogrel caused by high pressure, fast punching, and high temperature of the punch in French tableting. Even under a pressure exceeding 15kg/ mm2 , punching at a tablet speed of 130,000 tablets/hour, and a punch friction temperature exceeding 80°C, clopidogrel tablets have good stability. Before drug production, clopidogrel acid levoiso The isomer content was 0.20%, and the L-isomer content after production was 0.22%. No obvious chiral inversion and degradation of clopidogrel were detected. In particular, airgel-gluten is used as a stable carrier for clopidogrel. During long-term storage, the content of clopidogrel acid (impurity A), clopidogrel L-isomer (impurity C) It is always kept within a stable range, and the shelf life can be extended to more than 3 years. Greatly improved the safety of medication. |
| priorityDate | 2016-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.