| abstract |
The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives of formula (I) and 2,3-dihydro-1H-imidazo[1 , 2‑b]pyrazole derivatives and also compounds of formula (I'), wherein the variables have the meanings defined in the claims. The compounds according to the invention are useful as ROS1 inhibitors. The present invention further relates to methods for the preparation of such novel compounds, pharmaceutical compositions comprising the compounds as active ingredients and the use of the compounds as medicaments. |