abstract |
The present invention provides compositions comprising Eno1 for delivery to muscle. In addition, the present invention provides a method of normalizing blood sugar in a subject with elevated blood sugar, comprising administering enolase 1 (Eno1) to the subject, thereby normalizing blood sugar in the subject. The present invention also provides a method of treating one or more conditions in a subject, including impaired glucose tolerance, insulin resistance, prediabetes and diabetes, especially type 2 diabetes, the method comprising adding an enol Enzyme 1 (Eno1) is administered to a subject, thereby treating a disorder in the subject. In certain methods of the invention, Eno1 is delivered to muscle. |