abstract |
The present invention provides NO-releasing nitrooxy-alkylene-linked chromene conjugates having the structure of formula (I): wherein Z, R 1 , R 2 , R 3 , R 4 , X and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of formula (I) are provided; and the use of formula (I) Compounds that heal wounds, prevent and treat malignancies, and are useful methods of treating actinic keratoses, cystic fibrosis, and acne. |