| abstract |
The invention discloses a substituted oxazolidinone water-soluble derivative and application thereof, such as the pharmaceutically acceptable acid salt, solvate or hydrate represented by general formula I, wherein R1 is as defined in the description. In addition, the invention also discloses the synthesis method of the compound, the pharmaceutical composition and their application in the preparation of drugs for preventing or treating bacterial infection. Compared with the prior art, the novel substituted oxazolidinone water-soluble derivatives of the present invention have significant antibacterial infection activity, high bioavailability, very good water solubility (easy to inject), and convenient preparation Preparation, more stable curative effect, no incompatibility and safer clinical use. |