http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106083764-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 |
| filingDate | 2016-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106083764-B |
| titleOfInvention | A kind of chiral separation method for the high-purity intermediate being used to prepare AXL inhibitor |
| abstract | The present invention relates to a kind of high purity synthetic process for the intermediate being used to prepare Axl receptor protein tyrosine kinase inhibitor polyheteroaromatic substituted triazoles, and the method includes the steps of：A) raceme compound A is dissolved in the first organic solvent, the second organic solution of chiral acid is added dropwise, a large amount of solids are precipitated, after being added dropwise, heating is heated to that solid is entirely molten, and reaction solution is slowly cooled to room temperature and is stirred overnight, and the chiral hydrochlorate of a large amount of optical compounds A 1 is in solid precipitation；B) system obtained in step a is filtered under diminished pressure, by obtained solid in the in the mixed solvent of third organic solvent or third organic solvent and water, recrystallizes once or twice, obtain the chiral hydrochlorate of high-purity optical compounds A 1；C) optical compounds A 1 will be made after the chiral hydrochlorate basic hydrolysis obtained in step b；The chiral intermediate A 1 of high-purity can be obtained using this method, ee values are up to 99%, avoid passing through and prepare individual isomer using chiral chromatographic analysis method, and this method is simple to operate and friendly to environment, cost-effective, suitable industrial production. |
| priorityDate | 2016-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.