http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106083748-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8662946dce4b33afa8a58c32a462565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34e775f66b8b84f5da4941d474484275 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2016-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da0f70ffa9e854d77c7a16eb69f100be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c026396a10d4482a4ad345420e0c762 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9b7db2317586e1fe222a0d739a1157e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5beab7121146f4b978e01184413e9fb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40ea7e6e7feb2406bda5f17dd6222021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49fd390e5c30762abd86fc861a4a4d91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd2d46b99a5ff1d98a9f7ce28d856f0 |
| publicationDate | 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106083748-A |
| titleOfInvention | A kind of preparation method of Anastrozole |
| abstract | The invention provides a kind of preparation method of anastrozole, comprises the following steps: 1) with 5-bromomethyl-α, α, α', α'-tetramethyl-1, 3-benzenediacetonitrile and 4- Amino-1,2,4-triazole is used as a raw material, reacted in an organic solvent, and crystallized to obtain intermediate I, namely α, α, α′, α′-tetramethyl-5-[(4-amino -1,2,4-triazolyl)-methylene]-1,3-benzenediacetonitrile bromide salt; 2) intermediate I was dissolved in a solvent, added a small amount of water, acid and metal catalyst, under reflux Add sodium azide in batches, after the reaction is complete, filter while it is hot, concentrate the mother liquor to 0.25-0.75 times the original volume, cool and crystallize, filter the solid, extract it with base adjustment, and concentrate to obtain the crude product of anastrozole; 3) the anastrozole The crude product was dissolved in alcohol solvent, decolorized, cooled and crystallized to obtain the fine product of Anastrozole. The present invention avoids the generation of isanastrozole impurity that affects the drug efficacy from the source, and the isanastrozole is not detected, and the other simple impurities are less than 0.05%, and the total impurities are less than 0.2%. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110028458-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110028458-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109096146-A |
| priorityDate | 2016-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.