http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106083716-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 |
| filingDate | 2016-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106083716-B |
| titleOfInvention | A kind of preparation method of 3- aryl isoquinolines compound |
| abstract | The invention discloses a kind of preparation methods of 3- aryl isoquinolines compound, include the following steps：2- quinoline formyls benzyl amine derivative, alpha-brominated fragrant ethyl ketone, catalyst and additive are added in halogenated hydrocarbon solvent, 80~90 DEG C is heated to and is reacted, after the reaction was complete, post-processing purifying obtains intermediate；Then, intermediate, acid are added in ether solvent, are heated to 110~120 DEG C and are reacted, after the reaction was complete, vacuum distillation removes solvent；Alcohol and alkali are added into mixture, being heated to 60~70 DEG C, the reaction was continued, and after the reaction was complete, post-processing obtains the 3- aryl isoquinolines compounds；The preparation method is easy to operate, and reaction need not carry out under the conditions of anhydrous and oxygen-free, and raw material is commercially available, is simply obtained. |
| priorityDate | 2016-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.