http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106083702-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 |
| filingDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106083702-B |
| titleOfInvention | Pirfenidone derivative and preparation method thereof |
| abstract | The invention discloses I compound represented of formula or its pharmaceutically acceptable salt, crystal form, hydrate or solvates: where R 1 、R 2 、R 3 、R 4 、R 5 Separately or concurrently it is selected from H, halogen, hydroxyl, nitro, carbonyl or C 1 ~C 8 Alkyl；R 6 、R 7 Separately or concurrently it is selected from H, O=C-NH 2 , S=C-NH 2 , phenyl, methyl substituted phenyl, ethyl replace phenyl, methoxy-substituted phenyl, ethyoxyl replace phenyl.Compared with pirfenidone, noval chemical compound of the present invention has specific C=N-N structure, and the anti-fibrosis activity of noval chemical compound of the present invention is significantly better than pirfenidone, especially, noval chemical compound of the present invention is to the inhibiting rate of fibroblast proliferation, relative to pirfenidone increase rate at least 50% or more, simultaneously, noval chemical compound of the present invention is also significantly better than pirfenidone to the inhibitory effect of fibroblasts to secrete fibronectin, has good industrialization prospect. |
| priorityDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.