| abstract |
The invention discloses a preparation method of Arbidol hydrochloride. The invention innovatively uses cheap and easy-to-obtain p-nitrophenol as a raw material, and undergoes acetylation, nitro reduction, indole ring reaction, and methylation reaction. , bromination, thiophenolation and deprotection, Mannich reaction, and salt formation to obtain Arbidol hydrochloride; the whole synthesis process has mild reaction conditions, convenient source of raw materials, good product properties, high yield, few by-products, and reaction selectivity The method has high purity, is environmentally friendly, has low production cost, and is suitable for industrial production; it avoids the disadvantages of poor selectivity, many by-products, low yield, and the use of expensive catalysts and reagents that pollute the environment in the prior art. |