| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 |
| filingDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2019-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106074368-B |
| titleOfInvention |
PFKFB3 inhibitor and method as anticancer therapeutic agent |
| abstract |
It provided herein is noval chemical compounds, (E) -1- (pyridin-4-yl) -3- (7- (trifluoromethyl) quinoline -2- base) -propyl- 2- alkene -1- ketone: (E) -1- (pyridin-4-yl) -3- (7- (trifluoromethyl) quinoline -2- base) -propyl- 2- alkene -1- ketone is 6-phosphofructo-2-kinase/fructose -2, the inhibitor of 6- diphosphatase 3 (PFKFB3) has the property of surprisingly better in vitro and in vivo effect and pharmacokinetics.Also it provides, the pharmaceutical composition comprising compound and treats cancer and tumour in vivo using compound, and inhibit the method for glycolysis outflow and PFKFB3 enzymatic activity in cell. |
| priorityDate |
2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |