| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T29-49826 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-265
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J39-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J41-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J41-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-1864
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-3441
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J20-281
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-327
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-362
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-363
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3804 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-18 |
| filingDate |
2015-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106068150-B |
| titleOfInvention |
Sterile chromatography resins and their use in manufacturing processes |
| abstract |
The present invention provides a method of reducing the bioburden (e.g., sterilization) of a chromatography resin comprising exposing a container comprising a composition comprising a chromatography resin and at least one antioxidant and/or chelating agent to an amount sufficient to reduce the The γ-irradiation dose of the bioburden of the container and the chromatography resin, wherein the at least one antioxidant and/or chelating agent is sufficient to improve the γ-irradiation dose of the chromatography resin after/after being exposed to the γ-irradiation dose When the amount of loss of binding capacity is present. Also provided are bioburden-reduced chromatography columns comprising a bioburden-reduced chromatography resin, compositions comprising a chromatography resin and at least one chelating agent and/or antioxidant, performed using one of these bioburden-reduced chromatography columns A method of bioburden-reduced column chromatography, and an integrated, closed and continuous process for the bioburden-reduced production of purified recombinant proteins. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108114508-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108114508-B |
| priorityDate |
2014-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |