http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106047874-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106047874-B |
| titleOfInvention | A kind of deoxyribozyme molecules targeting SALL4 gene and the application in mastocarcinoma gene treatment |
| abstract | A kind of deoxyribozyme molecules targeting SALL4 gene and its application in mastocarcinoma gene treatment, belong to target gene technical field.The purpose of the present invention is being designed according to the mRNA sequence (NM_020436.4) of encoding human SALL4 and constructing deoxyribozyme molecules, nucleotide sequence is respectively as shown in SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3 and SEQ ID NO.4.Deoxyribozyme molecules designed by the present invention are a kind of small nut acid molecules that can identify and cut target-gene sequence, not only have high target-gene sequence cutting power, while having the chemical stability of antisense oligonucleotides, synthesis cost is low.By deoxyribozyme molecules to effective identification of target gene SALL mRNA sequence and high efficiency cutting, to inhibit proliferation, migration and the infiltration of breast cancer, final building is a kind of to realize the small nut acids drug of mastocarcinoma gene treatment by inhibiting SALL4 expression. |
| priorityDate | 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.