http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106047826-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y102-01004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53 |
| filingDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106047826-B |
| titleOfInvention | Aldehyde dehydrogenase, its recombinant expression transformants and the application in the synthesis of statin precursor |
| abstract | Aldehyde dehydrogenase, its recombinant expression transformants and the application in the synthesis of statin precursor.The present invention relates to a kind of catalytic activity height, the aldehyde dehydrogenase LeADH and its mutant that stereoselectivity is good, substrate tolerance is good, recombinant expression carrier and recombinant expression transformants containing the enzyme and mutant gene, recombinate the preparation of LeADH, and LeADH is preparing statins intermediate (3R, 5S) chloro- 2-6-, application in 4,6- tri- deoxidation-D- erythro pyranohexose lactones (CTeHL).The oxidizing ferment is the aldehyde dehydrogenase from long spore Lip river moral yeast, with NADP + For coenzyme, the reduced coenzyme NADPH of generation is reacted under the catalysis of nadph oxidase NOX, using oxygen as oxidant, realizes NADP + Oxidation regeneration.Compared with prior art, enzyme law catalysis of the present invention prepares the method chemical oxidizing agent seriously polluted without use environment of CTeHL, it is environmentally protective, and has many advantages, such as that reaction condition is mild, concentration of substrate is high, therefore had a good application prospect in the industrial production of blood lipid-lowering medicine statin intermediate. |
| priorityDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 341.