| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-36 |
| filingDate |
2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f6e02524fbbb1ecd647cc4895813288
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21572d409c724c610f8b081e71e53422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2466f5e0e36f4bfd34e52862a25b7a35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b994882049e06dbbd6a94d31895d539e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a206d38ddd4965772b9aee9a2b5c24eb |
| publicationDate |
2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106046015-A |
| titleOfInvention |
Specific probe substrates for CYP450 (cytochrome P450) 2A6 enzyme and application of specific probe substrates |
| abstract |
The invention discloses specific probe substrates for a CYP450 (cytochrome P450) 2A6 enzyme and an application of the specific probe substrates in determination of the activity of the CYP450 2A6 enzyme. The specific method for determining the activity of the CYP450 2A6 enzyme comprises the following steps: isopentene phenolic compound monomers such as isoglycycoumarin, isoglycyrol and 7-O-methylluteone are taken as the high-specificity probe substrates for the CYP450 2A6 enzyme, CYP catalytic reactions of the specific substrates are carried out by the aid of a CYP in-vitro incubation system, the activity of the CYP 2A6 enzyme in each biological sample is determined by quantitatively detecting product production amount or substrate consumption in unit time, and evaluation of the activity of the important drug metabolic enzyme CYP 2A6 enzyme is expected to be realized. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115197298-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115287330-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115287330-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115197298-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107090517-A |
| priorityDate |
2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |