http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106045971-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 |
| filingDate | 2016-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106045971-B |
| titleOfInvention | Pirfenidone derivatives and preparation methods thereof |
| abstract | The present invention relates to pirfenidone derivatives and a preparation method thereof. The present invention discloses a compound represented by formula I or its pharmaceutically acceptable salt, crystal form, hydrate or solvate: wherein, R 1 , R 2 , R 3 , R 4 , R 5 are selected from H, halogen, hydroxyl, nitro, carbonyl or C 1 -C 8 alkyl. Compared with pirfenidone, the new compound of the present invention has a different ring structure, and the anti-fibrosis activity of the new compound of the present invention is significantly better than that of pirfenidone, especially, the new compound of the present invention inhibits the proliferation of fibroblasts The rate has reached more than 95%, and compared with pirfenidone's 8.15%, the increase rate has reached more than 10 times. At the same time, the inhibitory effect of the new compound of the present invention on fibroblast secretion of fibronectin is also significantly better than pirfenidone. It has a good industrialization prospect. |
| priorityDate | 2016-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.