http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106045970-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106045970-B |
| titleOfInvention | The manufacturing method of 1- triazole -2- butanol derivs object |
| abstract | The purpose of the present invention is to provide it is a kind of a large amount of excessive 4- methylenepiperidines are not used to the opening of epoxy triazole by amine under mild conditions can method to manufacture the compound of formula 1 in high yield.This method is manufacture (2R, 3R) (2-2-, 4- difluorophenyl) -3- (4- methylenepiperidines -1- base) -1- (1H-1, 2, 4- triazol-1-yl) butane -2- alcohol or its acid-addition salts method, the method includes being selected from lithium, sodium, in the presence of the hydroxide or its hydrate of alkali metal or alkaline-earth metal in calcium and strontium, make (2R in reaction dissolvent, 3S) (2-2-, 4- difluorophenyl) -3- methyl -2- [(1H-1, 2, 4- triazol-1-yl) methyl] ethylene oxide reacted with 4- methylenepiperidines acid-addition salts. |
| priorityDate | 2010-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.