http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106045910-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b03ed3da9103d5f4afdf6dd60551aec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 |
| filingDate | 2016-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6e255f13a7c9b9023ae891505a3e91c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_674f067ca7e66ce1b776d28272c3ef31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d0d77a72228080eccfa496a6f44ffbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f7204dbedb2943cb2693fa54ed0df49 |
| publicationDate | 2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106045910-A |
| titleOfInvention | A kind of synthetic method of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid |
| abstract | The present invention relates to a kind of preparation method of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid. It comprises the following steps: ((A) reacting the diethyl ester compound shown in the following formula IV under the action of amine, alkali and carbonylating reagent to generate the acrylic acid diester compound shown in the following formula I, in: (B) make above-mentioned formula I compound react with fluorinated reagent, Lewis acid and methylhydrazine, generate the diester compound containing pyrazole ring shown in following formula II, (C) The heterocycle-containing diester compound shown in formula (II) reacts with a base to obtain 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxyl shown in formula III acid. The invention has the advantages that the required raw materials are easily available, the synthesis is simple and the process conditions are not harsh, the total yield can reach more than 80%, and the purity can reach more than 98%, which is suitable for industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114790173-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114790173-A |
| priorityDate | 2016-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.