| abstract |
The present application relates to borates and compositions and uses thereof as arginase inhibitors. Compounds of formula I are potent inhibitors of arginase I and II activity, wherein R 1 , R 2 , R 3 , R 4 , D, W, X, Y and Z are defined in the specification. The present invention also provides pharmaceutical compositions of the compounds and methods of their use in the treatment or prevention of diseases or conditions associated with arginase activity. |