http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105999420-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-414 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 |
| filingDate | 2016-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105999420-B |
| titleOfInvention | A kind of preparation method of the functionally gradient hydrogel for bone-cartilage reparation |
| abstract | The invention discloses a kind of preparation methods of functionally gradient hydrogel for bone-cartilage reparation, belong to technical field of biological materials.The method comprises the steps of firstly, preparing the identical double bond large biological molecule pre-polymerization liquid of two parts of mass fractions, then pre-polymerization liquid is prepared into the upper layer repair of cartilage pre-polymerization liquid comprising reparative factor nano particle respectively and lower layer's subchondral bone comprising calcium phosphorus nano particle repairs pre-polymerization liquid, based on suspension theory and photopolymerization reaction, the functionally gradient hydrogel that function changes with the variation of composition, structure is formed by the sedimentation of nano particle, diffusion.The biomim betatic that the present invention prepares has good biodegradability, biocompatibility, the growth factor of load is high-efficient, and sustained release performance is good, can induce the reparation of cartilage, subchondral bone, the two-way regeneration for realizing bone-cartilage, meets the reparation of articular cartilage damage. |
| priorityDate | 2016-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.