http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105999299-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105999299-B |
| titleOfInvention | A kind of small molecule micelle nano medicament carrying system and the preparation method and application thereof |
| abstract | The invention discloses a kind of small molecule micelle nano medicament carrying systems, belong to technical field of biological material.Drug-loading system of the present invention is the nano-micelle being self-assembly of by amphipathic molecule, the amphipathic molecule includes being connected directly the amphipathic molecule formed by hydrophilic drugs and hydrophobic segment, the nano-micelle can obtain rock-steady structure by internal crosslinking, the small molecule micelle nano medicament carrying system drugloading rate is high, it is convieniently synthesized, it is degradable.Hydrophilic drugs are formed amphipathic molecule by sensitive key connection with crosslinkable hydrophobic alkyl chain by the present invention, and are made into small molecule micella, and stability when it is recycled in vivo is improved being crosslinked inside micella.The amphipathic ligand with targeting can be added in small molecule micella, can be interrupted by actively and passively targeting arrival tumor tissues, then by sensitive key, to discharge drug molecule, kill cancer cell.The ligand with long circulating function can be also introduced in small molecule micella, improve Nano medication circulation time in vivo.The ligand that different hydrophilic drug can also be introduced in micella simultaneously, ultimately forms multiple medicine nanoparticle, reaches purpose associated with multiple medicine. |
| priorityDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.