http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105985341-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2015-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105985341-B |
| titleOfInvention | Kappa azoles type indole alkaloid and its purposes in anticomplement medicament is prepared |
| abstract | The invention belongs to field of traditional Chinese medicine pharmacy, is related to purposes of the kappa azoles type indole alkaloid in anticomplement medicament is prepared.The present invention new kappa azoles type indole alkaloid compound isolated from indigo naturalis powder, structure novel and unique, finds and the kappa azoles type indole alkaloids of 6 introducing substituted radicals first for nature, including compound (1) 1 (5,7 dihydroxy-pyridines simultaneously [3,2 b:5,6 b'] the double ketone of 6 ethane of indyl 2 and compound (2) N (2 hydroxy phenyl) 5,7 dihydroxy-pyridines simultaneously [3,2 b:5,6 b'] double formamides of indyl 6, confirm that the compound has the CH of stronger inhibitory action, wherein compound 1 and 2 to complement system classical pathway and alternative pathway activation using modern pharmacological research method 50 It is worth respectively 0.024 ± 0.007mg/ml, 0.032 ± 0.009mg/ml, AP 50 Value is respectively 0.056 ± 0.010mg/ml, 0.072 ± 0.014mg/ml.The compound can be used for preparing complement inhibitor. |
| priorityDate | 2015-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.