http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105968167-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105968167-B |
| titleOfInvention | The preparation method and its purposes as antineoplastic of epoxy toadpoison ketenes |
| abstract | The invention belongs to antitumor activity composition preparation field in the Chinese medicine dried venom of toads.The compound molecule formula C that the present invention is extracted 24 H 28 The bufalinone of 7 en of O, chemical name 7,14 epoxy, 3 α hydroxy 15, are named as epoxy toadpoison ketenes.Preparation method is：The sheet dried venom of toads is ground into coarse powder, respectively with petroleum ether, ethyl acetate, acetone, first alcohol and water heating and refluxing extraction, medicinal extract is recovered under reduced pressure to obtain in acetone extract;By acetone position medicinal extract by MCI posts, methanol-water gradient elution, thin-layer chromatography detection obtains 8 part Fr1 Fr8;Fr1 positions are passed through into glycol-based silicagel column CH 2 Cl 2 The stream part containing compound is collected in MeOH gradient elutions, the post methanol of Sephadex LH 20 elution, thin-layer chromatography detection；After concentration, crystallization is separated out, suction filtration goes out crystallization and produced.Zoopery shows that the compound has antineoplastic effect. |
| priorityDate | 2016-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.