http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105968085-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-64 |
| filingDate | 2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd3c987381a57b9c623125d8742da773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96ff19a1d10d03b08a277c81f0f6a12f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4488468a4e25de0103bdd6e4561b93e7 |
| publicationDate | 2016-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105968085-A |
| titleOfInvention | A kind of preparation method of L-tetrasubstituted phenylalaninol compound |
| abstract | The present invention provides a kind of preparation method of L-tetrasubstituted phenylalaninol (structural formula is as follows) having compound one general formula. Compound 1 is prepared from the known and readily available compound 3 in one step under ionic hydrogenation conditions, and can be converted into the corresponding L-tetrasubstituted phenylalaninol compound through amino protection and oxidation into acid. This kind of photoactive L-tetrasubstituted phenylalaninol and its corresponding amino acid compounds are very important for the asymmetric synthesis of tetrahydroisoquinoline alkaloids and derivatives such as Ecteinascidin 743, Phthalascidin 650, Zalypsis, etc. with high anticancer activity intermediates. This method overcomes some deficiencies in the previous synthesis, and has the advantages of simple steps, ideal yield, cheap and low toxicity of raw material reagents, simple and convenient operation, and easy industrialization. A good way to do it. |
| priorityDate | 2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.