http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105963706-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105963706-B |
| titleOfInvention | A kind of branching HPMA copolymer-DOX conjugate and its preparation method and application |
| abstract | The invention discloses a kind of branching N- (2- hydroxypropyl) Methacrylamide (HPMA) copolymer-DOX conjugates and its preparation method and application, belong to technical field of biological material.The present invention is successfully prepared a kind of branching HPMA copolymer-DOX conjugate using step RAFT polymerization.Adriamycin (DOX) is connected by pH sensitivity key with branching HPMA copolymer in the conjugate, and degradable segment is contained in the branching HPMA copolymer skeleton.The conjugate has good biocompatibility, sensitive characteristic with pH sensitivity and enzyme sensitivity, nanoparticle can be formed in tumor locus high aggregation as intelligent drug delivery system, and under tumor microenvironment rapid delivery of pharmaceuticals, be degraded into low molecular weight fraction, guarantee good biological safety while to improve antitumous effect, has broad application prospects in the treatment of tumour. |
| priorityDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.