http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105949174-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 |
| filingDate | 2016-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105949174-B |
| titleOfInvention | Carbazole sulfonamide derivative or its pharmaceutical salts and its preparation method and application |
| abstract | The present invention provides a kind of carbazole sulfonamide derivative or its pharmaceutical salts and its preparation method and application.The carbazole sulfonamide derivative or its pharmaceutical salts have following general formula (1), in the general formula (1), R 1 Selected from-CHO ,-M 1 OH、‑OM 2 、‑CH 2 ‑NH‑M 3 、‑COOM 2 Or-O-CH 2 ‑NH‑M 3 , and M 1 For low-grade alkylidene, M 2 For low alkyl group, M 3 For the alkyl for forming five yuan or hexatomic ring with-NH-；R 2 Selected from hydrogen, low alkyl group, lower alkoxy, benzyl, hydroxyl, sulfydryl, ester group, acyl group or amide groups.Carbazole sulfonamide derivative provided by the invention or its pharmaceutical salts water solubility are preferable, Antitubulin as small molecule not only has anti-micro-pipe effect, also there is excellent internal anti-tumor activity, the carbazole sulfonamide derivative or its pharmaceutical salts molecular weight are small simultaneously, and synthesis is simple and toxic side effect is small. |
| priorityDate | 2016-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.