http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105943496-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105943496-B |
| titleOfInvention | The adriamycin bonded pro-drug of galactose chitosan-polyethylene glycol polymer and its preparation and use of pH response |
| abstract | PH response adriamycin bonded pro-drug of galactose chitosan-polyethylene glycol polymer that the present invention relates to a kind of with neighboring group effect and preparation method thereof and purposes in medicine.It is characterized in that: (1) monomethyl ether polyethylene glycol first pass around carboxylated, then forms amido bond with amino in galactose chitosan, chitosan-polyethylene glycol medicine carrier is prepared；(2) amino in histidine and glutaraldehyde react to obtain the histidine with aldehyde radical；(3) amino on adriamycin is protected, then carries out the esterification of hydroxyl in histidine carboxyl and adriamycin, be then deprotected；(4) the histidine adriamycin ester containing aldehyde radical and chitosan-polyethylene glycol carry out schiff base reaction, and are restored with sodium cyanoborohydride；(5) carrier micelle is prepared by dialysis；(6) carrier micelle prepared by has good pH responsiveness and hepatic targeting, can further develop to treat the novel targeted preparation of liver cancer. |
| priorityDate | 2016-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.