http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105936637-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2016-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105936637-B |
| titleOfInvention | A kind of preparation method of ticagrelor |
| abstract | The invention discloses a kind of preparation methods of ticagrelor.Compound 1- [(3aR in preparation method of the invention, 4S, 6R, 6aS)-[[2,2- dimethyl-tetrahydro-4H- cyclopenta-1, the amyl- 4- oxygroup of 3- dioxane] ethyl acetate]-6- base]-5- amino-4- cyano-1,2,3- triazole (II) and (1R, 2S) (3-2-, 4- difluorophenyl) the obtained compound III of cyclopropylamine reaction, then compound III is finally obtained finished product ticagrelor (I) by substitution, reduction and hydrolysis in an aqueous medium with carbon disulfide prepare compound IV.The reaction is raw materials used at low cost, and process route is simple, and reaction condition is mild, and environmental pollution is low, is suitble to industrialized production. |
| priorityDate | 2016-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.