http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105934431-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-44 |
| filingDate | 2015-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105934431-B |
| titleOfInvention | Preparation method of substituted urea compounds |
| abstract | The present invention relates to a compound having the structure of formula A, a preparation method of a pharmaceutically acceptable salt or derivative thereof, or a preparation method of a substituted urea compound of formula IIa, a pharmaceutically acceptable salt or ester thereof, ( The method of formula IIa) comprises the reaction of an imidazole intermediate of formula IIa' with a carbamoyl halide of formula R1R2NC(=O)Hal, wherein Hal represents Cl, F, I or Br, wherein the intermediate of formula IIa' is passed through Oxidation of derivatives of R5 and R6, R6-C(=O)CH 2 R5 forms glyoxal intermediate R6-C(=O)(C=O)R5, which is then prepared by treating with ammonium hydroxide and aldehyde R8CHO, wherein the compound substituents are as defined herein. |
| priorityDate | 2014-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.