http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105924500-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105924500-B |
| titleOfInvention | A kind of Carfilzomib prodrug and preparation method thereof |
| abstract | The present invention provides a kind of Carfilzomib prodrugs, have structure shown in formula (I).The present invention is using the peg molecule of short chain as water-wet side, Carfilzomib is as hydrophobic side, two parts are connected in the way of at imine linkage by L-Leu, novel Carfilzomib prodrug is prepared, improve the water solubility of Carfilzomib, it is easily prepared at highly concentrated solution, it is freeze-dried that finished product, stability enhancing is made.Simultaneously, the Carfilzomib prodrug is acid-sensitive compound, with the holding stabilization in blood (alkalescent) circulation, and it once reaches in tumor tissues (slant acidity), the characteristics of Carfilzomib raw medicine can then be discharged rapidly out, to realize target administration, toxic side effect is reduced while enhancing chemotherapeutic efficacy. |
| priorityDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.