| abstract |
The present invention relates to a substituted aminopyrimidine compound and its use and application, in particular to a new aminopyrimidine compound and its free form or pharmaceutically acceptable salt and preparation form as a treatment for disorders or diseases related to PI3-kinase abnormalities use of the drug. The present invention also relates to the use of pharmaceutical compositions comprising the compounds of the present invention in the treatment of mammals, in particular human disorders or diseases associated with abnormalities in PI3-kinase, e.g. Treatment of PI3-kinase-regulated immune and inflammatory diseases, and proliferative diseases associated with PI3-kinase activity, including but not limited to leukemia and solid tumors. |