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filingDate 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-105920678-B
titleOfInvention A kind of preparation method of the alginate porous material with three-dimensional gradient pore structure
abstract The invention discloses a kind of preparation methods of the alginate porous material with three-dimensional gradient pore structure, its using relative molecular mass 100,000 or more sodium alginate or oxidized sodium alginate as solute, deionized water, distilled water, physiological saline, water for injection or ringer's solution are solvent, in moulding mould special, by the temperature gradient freeze forming for forming vertical direction, crosslinked reaction again, up to inside at cellular, including a number of hole, from lower surface to upper surface, each hole aperture is respectively from big to small at gradient, wherein, the aperture of upper surface is 5-70 μm, the aperture of lower surface is 50-200 μm, it is penetrated through each other per adjacent holes, porous material with skin biomimetic features.Preparation process of the present invention is simple, easily-controllable, and manufacturing cost is low, obtained good product quality, stay in grade, with skin simulation architecture, with good water imbibition, biodegradability and biocompatibility.
priorityDate 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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