http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105906732-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 |
| filingDate | 2016-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105906732-B |
| titleOfInvention | With organosilan synthesizing sand sagebrush polysaccharide sulfate and its application |
| abstract | The invention discloses one kind to use organosilan synthesizing sand sagebrush polysaccharide sulfate and its application, and method includes：A. the preparation of polysaccharide solution；B. the preparation of artemisia desertorum polysaccharide silicon ether derivant；C. the preparation of esterifying reagent；D. sulfating reaction;E. the removing of protection group.The larger tert-butyl diphenyl chlorosilane protection artemisia desertorum polysaccharide primary hydroxyl of utilization space steric hindrance, regio-selective synthesis sand sagebrush polysaccharide sulfate, has expanded application of the artemisia desertorum polysaccharide as natural active matter.Silicon ether derivant is high to the degree of stability of acid in the present invention, polysaccharide primary hydroxyl can be preferably protected in sulfuric acid esterification, the substitution value and molecular weight of product can be optimized by the proportion adjustment of sulfur acidizing reagent, to improve polysaccharide derivates quality requirement.The sand sagebrush polysaccharide sulfate of synthesis is applied to prepare in cancer therapy drug as the inhibitor of Hela cervical cancer cells. |
| priorityDate | 2016-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.