http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105884625-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-10 |
| filingDate | 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105884625-B |
| titleOfInvention | A kind of synthetic method of R-salmeterol |
| abstract | The present invention provides a kind of synthetic method of R-salmeterol (V), described synthetic method is: compound (I) and N-benzyl-6-(4-phenylbutoxy)-1-hexane Amine reaction obtains compound (II); Compound (II) obtains compound (III) under acidic condition hydrolysis; Compound (III) obtains compound (IV) through asymmetric reduction; Compound (IV) deprotection obtains R Salmeterol ( V); The route of the present invention is simple, with 2-acetoxy-5-(2-bromoacetyl) benzyl acetate and N-benzyl-6-(4-phenylbutoxy)-1-hexylamine As a raw material, the target product R-salmeterol is obtained through 4-step reactions in total. The synthetic method of the present invention has mild reaction conditions, easy and convenient operation, high yield, good stereoselectivity, low production cost, is suitable for industrialized production, and has great practical potential. Application value and socio-economic benefits. |
| priorityDate | 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.