http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105879062-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 |
| filingDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105879062-B |
| titleOfInvention | Three mode targeted contrast agent of lung non-small cell carcinoma optics and its preparation method and application |
| abstract | The present invention relates to one kind based on three mode targeted contrast agent of lung non-small cell carcinoma CT/MR/ near-infrared optical and its preparation method and application, and preparation method includes: that the amino terminal of the 5th polyamide-amine dendrimer is modified with DOTA-NHS；Folid acid is then connected to by dendrimer by polyethylene glycol；Then further modified with Cy5.5；Using the dendrimer after modifying as template, gold nano grain is prepared by sodium borohydride reduction, gadolinium ion is sequestered in macromolecular later；Whole acetylation process finally are carried out to the amino of dendrimer surface residual；Solution after reaction is dialysed, freeze-drying process obtains finished product；External, internal three mode radiography performance of CT/MR/ near-infrared optical is carried out to product to evaluate.The method of the present invention is simple and easy, has the inside and outside lung non-small cell carcinoma cell-targeting effect of good body, has potential targeting CT/MR/ near-infrared optical radiography application prospect. |
| priorityDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.