| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_364361dcadbe698011b0554cccff370b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C223-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 |
| filingDate |
2014-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e7cad3298c41818405b167fd8a27235 |
| publicationDate |
2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105873589-A |
| titleOfInvention |
Process for producing benzoquinoline compounds |
| abstract |
The present invention relates to novel methods for the manufacture of benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2) and intermediates thereof. The present invention relates to a novel process for the preparation of benzoquinoline compounds of formula (I), including tetrabenazine and deuterated tetrabenazine analogs such as d6 - tetrabenazine. Tetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor and is commonly prescribed for the treatment of Huntington's disease. d 6 ‑tetrabenazine is a deuterated analog of tetrabenazine that has improved pharmacokinetic properties compared to the non-deuterated drug and is currently in clinical development. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111960999-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111960999-A |
| priorityDate |
2013-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |