http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105861549-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2016-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105861549-B |
| titleOfInvention | Preparation method and application of blue up-conversion nano gene vector doped with rare earth thulium element |
| abstract | The invention relates to a preparation method and application of a blue upconversion nano gene vector doped with rare earth thulium. The method comprises the following steps: 1) preparing blue rare earth upconversion nanoparticles doped with rare earth thulium elements: the blue up-conversion nanoparticles are prepared by a solvothermal method, and the prepared diameter is 20-50 nanometers; 2) preparing water-soluble carboxylated rare earth thulium element-doped blue up-conversion nanoparticles by adopting a ligand exchange method; 3) the surface of the blue upconversion nanoparticle doped with the rare earth thulium element is connected with polyetherimide with the molecular weight of 600. The gene transfection efficiency of the gene nano-carrier of the rare earth thulium element doped blue up-conversion gene nano-carrier tracking the exogenous gene in real time is 40-70%, and the cell survival rate is 80-95%. The carrier can also detect the position converted on blue by irradiating 980 nm near-infrared light to track the target position reached by the gene in real time. |
| priorityDate | 2016-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.