| abstract |
The present invention belongs to the field of pharmaceutical preparations, and relates to a polypeptide drug delivery system, particularly to a micelle preparation entrapped with binding peptide polymer with specific anti-cancer activity. The drug delivery system consists of a targeted functional material, an amphiphilic block copolymer and a binding peptide. By entrapping a binding peptide capable of restoring the activity of a tumor suppressor protein p53, the binding peptide is delivered into cancer cells to exert the activity of inhibiting tumor cell growth and increase targeted anti-cancer effect; and the binding peptide has better anti-cancer effect by combination with temozolomide. By in vivo and in vitro active valuation, the drug delivery system is proved to be able to successfully deliver binding peptides to the target site and send binding peptides into the target cells, and has clear therapeutic effect. |