| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92d71a3e23389a3bca747290fc6464cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fcb09d561162847dcb226388ebf67d9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate |
2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f05d1b2d9a1245c0b19f244bc48a0b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a3ca9ebd3d8da377e06a78161e9d6cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1776f66b3220b22c6f0c11bf13dc5b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18c28f023688b7c37df916bb255c853b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d7d4b4d348be23e84d11ce12b5cb26b |
| publicationDate |
2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105849128-A |
| titleOfInvention |
Human antibodies against aggrecanase-type ADAMTS species for use in the treatment of aggrecanase-associated diseases |
| abstract |
The present invention provides antibodies that specifically bind to human aggrecanase and inhibit the enzymatic activity of human aggrecanase. In one embodiment, the aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a specific epitope in human ADAMTS4 and inhibits not only the aggrecanase activity of human ADAMTS4 but also the aggrecanase activity of human ADAMTS5. In addition, the present invention also provides the use of the antibody in preventing or treating the progression of arthritis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111032695-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110997716-A |
| priorityDate |
2013-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |