http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105837658-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 |
| filingDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105837658-B |
| titleOfInvention | A kind of synthetic method of argatroban |
| abstract | The invention discloses a synthetic method of argatroban. The synthesis method comprises: under the condition of catalytic transfer hydrogenation reaction, in the presence of a catalyst, the compound II having the structure shown in the following formula II is contacted with a hydrogen donor to obtain the crude product of argatroban, wherein the hydrogen donor is formic acid or formate, According to the synthesis method of the above argatroban provided by the present invention, formic acid or a formate salt is used as a hydrogen donor, and the compound II is hydrogenated and reduced to obtain argatroban. In the process of hydrogenation reduction of compound II, the synthetic method adopts catalytic hydrogenation transfer hydrogenation reaction instead of catalytic hydrogenation reaction, which not only simplifies the operation steps, avoids the technical and safety problems caused by the use of hydrogen, but also reduces the The danger of the reaction and the mild and easy-to-control reaction conditions are more suitable for the industrial scale-up production of argatroban. |
| priorityDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.