http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105837642-A

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
filingDate 2016-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88cea083b4d743551b7ecb1d62ef30f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05072d61afc98cc68466a02506074e42
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publicationDate 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-105837642-A
titleOfInvention Polyacid Schiff base compound and its synthesis method and use
abstract The invention discloses a polyacid Schiff base compound and its synthesis method and use. The polyacid Schiff base compound comprises methylimidazole counter cations and methylimidazole sandwich heteropoly acid fragments and belongs to a single crystal triclinic system. The polyacid Schiff base compound has a structural formula shown in the description. The synthesis method comprises putting an ammonium heptamolybdate solution in a container, dropwisely adding hydrochloric acid into the solution to obtain a solution a, dropwisely adding a new prepared methanol solution of [Mn(salpn)(H2O)]2(ClO4)2 into the solution a to obtain a solution b, carrying out microwave radiation heating for a reaction for 5-7min, carrying out cooling and filtration, sealing the filtrate through a film with pores, carrying out slow volatilization for 7-10 days to obtain blocky crystals, washing the blocky crystals through methanol and carrying out natural drying in air to obtain a desired product. The polyacid Schiff base compound is used in preparation of a drug for resisting cancers. In the novel compound synthesis, a final product is prepared under microwave radiation so that a compound yield is greatly improved. The monocrystalline structure provides novel data for a crystal database. A biological activity test proves that the polyacid fragments further improve antineoplastic effects of a Schiff base precursor.
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